3D scaffold fabrication by mask projection excimer laser stereolithography

Year: 2014

Authors: Beke S., Farkas B., Romano I., Brandi F.

Autors Affiliation: Nanophysics Department, Istituto Italiano di Tecnologia Via Morego 30, 16163-Genova, Italy; Istituto Nazionale di Ottica, CNR, Via G. Moruzzi 1, 56124-Pisa, Italy

Abstract: The production of 3D scaffolds with well-controlled architecture at the micrometer-scale is a fundamental issue for the advancement of tissue engineering towards applications in health care. Stereolithography is a highly versatile and accurate technique to fabricate 3D scaffolds with controlled architectures. Here, a scalable stereolithography method combining mask projection with excimer laser is reported. Its capability is showcased by a variety of mm-sized 3D biodegradable scaffolds patterned with a spatial resolution well-suited for tissue engineering applications. The presented method offers a concrete possibility to scale-up stereolithography-based production of 3D scaffolds to be used in regenerative medicine with potentially high-impact on health care. (C) 2014 Optical Society of America

Journal/Review: OPTICAL MATERIALS EXPRESS

Volume: 4 (10)      Pages from: 2032  to: 2041

More Information: The authors gratefully thank Alice Scarpellini for SEM imaging. This work has received funding support from the EC (FP7-NMP-2013-EU-China), grant agreement n.604263 (NEUROSCAFFOLDS).
KeyWords: BIODEGRADABLE PHOTOPOLYMER SCAFFOLDS; LASER STEREOLITHOGRAPHY; MICROSTRUCTURES; Excimers
DOI: 10.1364/OME.4.002032

Citations: 21
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